It is generally considered that the absorption of Mg is inversely related to the ingested dose. The objective of the present study was to determine if the mode of administration (bolus v. consumption throughout the day) could influence Mg bioavailability from Mg-rich natural mineral water comparing the same nutritional Mg amount (126mg). Using a 2d cross-over design, twelve healthy men were asked to drink 1·5 litres Mg-rich mineral water either as 2×750ml or 7×212ml throughout the day. Two stable isotopes (25Mg and 26Mg) were used to label the water in order to distinguish both regimens. Fractional apparent Mg absorption was determined by faecal monitoring and Mg retention was determined by measuring urinary excretion of Mg isotopes. Higher Mg absorption (50·7 (sd 12·7) v. 32·4 (sd 8·1) %; P=0·0007) and retention (47·5 (sd 12·9) v. 29·0 (sd 7·5) %; P=0·0008) from Mg-rich mineral water were observed when it was consumed in seven servings compared with larger servings. Thus, regular water consumption throughout the day is an effective way to increase Mg bioavailability from Mg-rich mineral water
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机译：通常认为，Mg的吸收与摄入剂量成反比。本研究的目的是确定与相同营养含量（126mg）相比，施用方式（全天推注与全天消耗）是否会影响富含镁的天然矿泉水中的镁生物利用度。使用2d交叉设计，要求十二名健康男人全天喝2×750ml或7×212ml的1·5升富含Mg的矿泉水。为了区分这两种方案，使用了两种稳定的同位素（25Mg和26Mg）标记水。通过粪便监测确定表观的Mg吸收分数，并通过测量Mg同位素的尿排泄确定Mg保留率。较高的Mg吸收（50·7（sd 12·7）v。32·4（sd 8·1）％; P = 0·0007）和保留（47·5（sd 12·9）v。29·0（与大份量食用相比，七份食用富含镁的矿泉水可观察到sd 7·5）％； P = 0·0008）。因此，全天定期饮水是增加富含镁的矿泉水镁生物利用度的有效方法
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